boostDM documentation

BoostDM is a method to score all possible point mutations (single base substitutions) in cancer genes for their potential to be involved in tumorigenesis.

The method has been described and used in this study:

In silico saturation mutagenesis of cancer genes

Ferran Muiños, Francisco Martinez-Jimenez, Oriol Pich, Abel Gonzalez-Perez, Nuria Lopez-Bigas

DOI: 10.1038/s41586-021-03771-1

URL: https://www.nature.com/articles/s41586-021-03771-1

These docs will guide you through the description, resources and practicalities of the method.

Contents

• Resources
• Motivation
• BoostDM overview
• BoostDM in detail
• Validation
• Discovery index
• Pipeline
• References